Modeling long-term diabetes and related complications in rats

Drug induced diabetes,

Tartalom

    Modeling long-term diabetes and related complications in rats J Pharmacol Toxicol Methods.

    diabétesz napló

    Mar-Apr ; Epub Nov Gyömrői út Electronic address: erika. DOI: The aims of this study were to establish a model of long-term diabetes with sustained medium scale hyperglycemia and characterize the pathological changes detectable after 4months, with particular respect to dependence on the degree of hyperglycemia.

    cukor diabétesz a gyermekek 3 éves kezelés

    Methods: Streptozotocin-induced diabetic CFY rats drug induced diabetes subjected to four different insulin substitution protocols to achieve different levels of glycemic control Diabetic groups.

    Eyes were investigated by ophthalmoscopy, kidney function by urine analysis, and neuropathy by functional tests.

    kezelése hijama cukorbetegségben

    Retinal and renal morphological evaluations were performed by histology, immuno-histochemistry and electron microscopy. Discussion: We established a treatment protocol in rats enabling complex investigation of diabetic retinopathy, nephropathy and neuropathy on a long-term period.

    alacsony és magas vércukorszint tünetei

    Clearly hyperglycemic dependent parameters of these complications serve as good outcome measures for preclinical trials. Our results provide a useful basis for designing studies for testing preventative treatments as well as other translational medical research in this field.

    cukorbetegség 2 fajta kezelés a következmények

    Keywords: Anterior segment neovascularization; Chronic model; Cold allodynia; Diabetic nephropathy; Diabetic neuropathy; Diabetic retinopathy; Drug development; Insulin implant; Preclinical model; Streptozotocin. Copyright © Elsevier Inc. All rights reserved.

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